Situations where a liquid covers a surface have been extensively studied because of their ubiquity (e.g., painting, inkjet drops…). This phenomenon, known as dynamic wetting, is nowadays well understood when liquids spread on flat solid substrates. Nevertheless, real life substrates are neither atomically flat nor passive. A difficulty to describe it comes from the broad range of length scales involved, from the millimeter size of a drop to the nanometric range of the liquid/substrate interaction. The aim of this internship is to understand how nanometric roughness is correlated to the wetting dynamics. Through a multidisciplinary approach combining physics and surface chemistry, we propose systematic model experiments that allow a multi-scale visualization and characterization of the spreading of a polymeric liquid.