During multicellular development, a large diversity of cell-types is generated from small pools of progenitor cells. To achieve ordered and timely generation of each cell-type, progenitor cells assess cues along two primary sources of information: space and time. In the most classic example for the acquisition of spatial cell identities, cells interpret a position-dependent concentration of a diffusible morphogen to spatially pattern into various cell-types. While quantitative and predictive descriptions of morphogen decoding for spatial identity have emerged over the past decades, similar “cellular rules” for temporal patterning have not been uncovered. In this project, we will use post-embryonic temporal patterning of hypodermal blast cells (HBCs) in the nematode C. elegans as a model system, which are uniquely qualified to overcome current limitation of in vivo studies. Through live-imaging with microfluidics, quantitative image analysis, and mathematical modelling, the goal of this internship is to uncover how cells interpret temporal cues to generate sequences of temporal identities during development. The overall goal of this work is to synthesize intuitive and predictive principles for cellular decision-making in the temporal domain, bound to generalize to other systems such as invertebrate or vertebrate nervous systems.