Biological tissues consist of adherent cells acting as active agents that consume ATP to generate mechanical work. Cell–cell adhesion transmits these forces, driving global tissue deformations through collective rearrangements, as in morphogenesis. While artificial cells containing filament/motor systems show strong membrane deformations, no active biomimetic tissue yet exists to quantitatively study how internal activity shapes collective dynamics, plasticity, and rheology. Combining instrumentation, physics, biophysics, and biochemistry, this project aims to build such artificial tissues from networks of droplets linked by lipid bilayers (Droplet Interface Bilayers) that encapsulate active systems: microtubule/kinesin, actin/myosin, or hybrids. By tuning internal activity, filament composition, and droplet adhesion, we will examine how these parameters govern emergent collective behavior. Filament velocity fields inside droplets will be measured and correlated with interface deformations. At the tissue scale, we will track T1 neighbor exchanges as markers of fluidization and plasticity, and spatial correlations in droplet displacements to extract activity-dependent collective modes. Controlled perturbations will include network geometry (1D or 2D), ATP gradients via structured illumination, and tuning of membrane/filament coupling through specific protein anchoring. We aim to identify the minimal properties of active agents that drive collective tissue behavior.