In the framework of optical quantum computing and communication, a crucial goal consists in controlling the interaction between single atoms and single photons. This led to the development of cavity-QED, where natural or artificial atoms efficiently interact with confined photons. Many demonstrations were also performed in the simplified framework of waveguide-QED, exploiting the direct coupling of atoms to photonic waveguides, fibers, and on-chip photonic circuits Our team in C2N has developed quantum-dot-based interfaces which can be used as efficient emitters of single photons: this led to the creation of the company Quandela. A strong challenge remains: developing quantum nodes that implement quantum logic operations on incoming photons. In such context, we use our light-matter interfaces as efficient receivers (and not just emitters) of quantum light. In recent years, we realized that a breakthrough can also be obtained on the theory side: it becomes possible to describe many complex cavity-QED phenomena with the simpler framework of waveguide-QED . This allows implementing numerical and analytical strategies which were previously out of reach. We now want to explore the potential of this breakthrough for spin-photon interfaces. We want to describe novel spin-photon and photon-photon entanglement schemes and to develop a simulation platform that any experimentalist could use, to predict the results of complex experiments with a variety of light-matter interfaces.